EX VIVO HUMAN SKIN MODEL (OECD 428 Compliance)
- An alternative to animal use for Chemical, Pharmaceutical and Cosmetic testing
- Ex vivo Human skin is considered the best surrogate for in vivo Human skin
- Ex vivo skin explant sources: Ex vivo Human skin tissues are obtained from patients undergoing plastic surgery
- Consent form: Patients are anonymous and agreed to give their skin by signing a consent form
- Collecting, processing and storage of Human skin tissues are compliance with legal and ethical requirements
- Ex-vivo Human skin models Sources: Adult skin samples from different parts of the body (exemple: abdomen, arm, lift)
- Full-thickness or Dermatomized (OECD 428 according to Skin Absorption) (or custom formats)
- Frozen, Donor information includes age, sex, ethnicity, skin localization, phototype
- All donors are HIV 1 & 2, hepatitis B and C viruses negative
- Applications of the skin explant model: Ex-vivo skin tissues samples can be used in efficacy and safety testing of new compound.
- Validated by EU/Indian CROs for OECD 428 Skin Absorption assay and IVPT assays under GLP validation study
Skin Discs preparation after Surgery
Different Products from Skin Processing
After skin processing, different parts of the skin are separated and used for various applications. Here are the key parts obtained:
Skin Products List
